Keeslar was born in Grand Rapids, Michigan, the son of Fred Keeslar and Ann Ferguson, who divorced in 1977.

Keeslar is known for his roles in The Last Days of Disco, Scream 3, the 2000 miniseries Frank Herbert's Dune and that of Stephen King's Rose Red. Keeslar starred in the 2008 ABC Family series The Middleman.

Keeslar is known for his roles in The Last Days of Disco, Scream 3, the 2000 miniseries Frank Herbert's Dune and that of Stephen King's Rose Red. Keeslar starred in the 2008 ABC Family series The Middleman.